构建和发展了“以活性单体化合物为探针发现药物靶标”的新药研究技术...
构建和发展了“以活性单体化合物为探针发现药物靶标”的新药研究技术体系，通过整合抗毒力因子活性分析和活体成像等多种技术建立了抗菌活性单体化合物多水平体内外筛选模型，用以发现探针化合物；利用生物芯片技术结合多种分子生物学手段建立了药靶高通量分析和确证平台，用以挖掘基于探针化合物的新药靶。在国内外杂志上发表研究论文87篇（其中SCI50篇）。近3年发表SCI论文18篇，其中第一作者和通讯作者SCI论文16篇；授权专利4项；参与出版著作2部。
1.发表论文
YuL,ZhangW,WangL,YangJ,LiuT,PengJ,LengW,ChenL,LiR,JinQ.TranscriptionalProfilesoftheResponsetoKetoconazoleandAmphotericinBinTrichophytonrubrum.AntimicrobAgentsChemother.2007,51(1):144-153.(影响因子:4.672,第一作者)
YuL,LingG,DengX,JinJ,JinQ,GuoN.InVitroInteractionbetweenFluconazoleandTriclosanagainstClinicalIsolatesofFluconazole-ResistantCandidaalbicansDeterminedbyDifferentMethods.AntimicrobAgentsChemother.2011,55(7):3609-3612.(影响因子:4.672,第一作者)
QiuJ,WangD,XiangH,FengH,JiangY,XiaL,DongJ,LuJ,YuL,DengX.SubinhibitoryconcentrationsofthymolreduceenterotoxinsAandBandα-HemolysinproductioninStaphylococcusaureusisolates.PLoSOne.2010,5(3):e9736.(影响因子:4.61,通讯作者)
HuaXiang,QiJin,DachengWang,WeiWang,NaGuo,HaihuaFeng,XudongTang,RizengMeng,KaiyuZhang,LihuiLiu,JunchaoLiang,FenggeShen,MingxunXing,XumingDeng,LuYu.Transcriptionalandfunctionalanalysisoftheeffectofmagnolol:inhibitionofautolysisandbiofilmsinStaphylococcusaureus.PLoSOne.2011,6(10):e26833.(影响因子:4.61,通讯作者)
ZhangW,YuL,LengW,WangX,WangL,DengX,YangJ,LiuT,PengJ,WangJ,LiS,JinQ.cDNAmicroarrayanalysisoftheexpressionprofilesofTrichophytonrubruminresponsetonovelsyntheticfattyacidsynthaseinhibitorPHS11A.FungalGenetBiol.2007,44(12):1252-1261.(影响因子:3.255,并列第一作者)
YuL,GuoN,MengR,LiuB,TangX,JinJ,CuiY,DengX.Allicin-inducedglobalgeneexpressionprofileofSaccharomycescerevisiae.ApplMicrobiolBiotechnol.2010,88(1):219-229.(影响因子:3.583,第一作者)
YuL,XiangH,FanJ,WangD,YangF,GuoN,JinQ,DengX.GlobalTranscriptionalResponseofStaphylococcusaureustoRhein,aNaturalPlantProduct.JBiotechnol.2008,135(3):304-308.(影响因子:3.225,第一作者)
YuL,ZhangW,LiuT,WangX,PengJ,LiS,JinQ.GlobalgeneexpressionofTrichophytonrubruminresponsetoPH11B,anovelfattyacidsynthaseinhibitor.JApplMicrobiol.2007,103(6):2346-2352.(影响因子:2.798,第一作者)
YuL,GuoN,YangY,WuX,MengR,FanJ,GeF,WangX,LiuJ,DengX.Microarrayanalysisofβ-anisaldehyde-inducedtranscriptomeofSaccharomycescerevisiae.JIndMicrobiolBiotechnol.2010,37(3):313-322.(影响因子:2.465,第一作者)
GuoN,YuL,MengR,FanJ,WangD,SunG,DengX.GlobalgeneexpressionprofileofSaccharomycescerevisiaeinducedbydictamnine.Yeast.2008,25(9):631-641.(影响因子:2.422,并列第一作者)
WangD,YuL,XiangH,FanJ,HeL,GuoN,FengH,DengX.GlobalTranscriptionalProfilingofStaphylococcusaureusTreatedwithBerberineChloride.FEMSMicrobiolLett.2008,279(2):217-225.(影响因子:2.269,并列第一作者)
BiX,GuoN,JinJ,LiuJ,FengH,ShiJ,XiangH,WuX,DongJ,HuH,YanS,YuC,WangX,DengX,YuL.TheglobalgeneexpressionprofileofthemodelfungusSaccharomycescerevisiaeinducedbythymol.JApplMicrobiol.2010,108(2):712-722.(影响因子:2.798,通讯作者)
GuoN,LiuJ,WuX,BiX,MengR,WangX,XiangH,DengX,YuL.Antifungalactivityofthymolagainstclinicalisolatesoffluconazole-sensitiveand-resistantCandidaalbicans.JMedMicrobiol.2009,58(Pt8):1074-1079.(影响因子:2.65,通讯作者)
JinJ,ZhangJ,GuoN,FengH,LiL,LiangJ,SunK,WuX,WangX,LiuM,DengX,YuL.TheplantalkaloidpiperineasapotentialinhibitorofbromideeffluxinethidiumMycobacteriumsmegmatis.JMedMicrobiol.2010,11,60(Pt2):223-229.(影响因子:2.65,通讯作者)
GeF,ZengF,LiuS,GuoN,YeH,SongY,FanJ,WuX,WangX,DengX,JinQ,YuL.Invitrosynergisticinteractionsofoleanolicacidincombinationwithisoniazid,rifampicinorethambutolagainstMycobacteriumtuberculosis.JMedMicrobiol.2010,59(Pt5):567-572.(影响因子:2.65,通讯作者)
ZhangX,LiH,FengH,XiongH,ZhangL,SongY,YuL,DengX.Valnemulindownregulatesnitricoxide,prostaglandinE2,andcytokineproductionviainhibitionofNF-kappaBandMAPKactivity.IntImmunopharmacol.2009,9(7-8):810-816.(影响因子:2.468,通讯作者)
GuoN,WuX,YuL,LiuJ,MengR,JinJ,LuH,WangX,YanS,DengX.InVitroandInVivoInterractionsbetweenFluconazoleandAllicinagainstClinicalIsolatesofFluconazole-ResistantCandidaalbicansDeterminedbyAlternativeMethods.FEMSImmunolMedMicrobiol.2010,58(2):193-201.(影响因子:2.201,通讯作者).
ZhangX,XiongH,LiH,YuL,DengX.EffectsofflorfenicolonLPS-inducednitricoxideandprostaglandinE(2)productioninRAW264.7macrophages.FundamClinPharmacol.201125(5):591-598.(影响因子:2.152,通讯作者).
JinJ,ZhangJY,GuoN,ShengH,LiL,LiangJC,WangXL,LiY,LiuMY,WuXP,YuL.Farnesol,aPotentialEffluxPumpInhibitorinMycobacteriumsmegmatis.Molecules.2010,15(11):7750-7762.(影响因子:1.974,通讯作者)
Guo-xingLiu,Jun-ChaoLiang,Xue-LinWang,Zhao-HuiLi,WeiWang,NaGuo,Xiu-PingWu,Feng-GeShen,Ming-XunXing,Li-HuiLiu,LeiLi,Ming-YuanLiu,LuYu.InVitroSynergyofBiochaninAandCiprofloxacinagainstClinicalIsolatesofStaphylococcusaureus.Molecules.2011,16(8),6656-6666.(影响因子:1.974,通讯作者)
GuoxingLiu,HuaXiang,XudongTang,KaiyuZhang,XiupingWu,XuelinWang,NaGuo,HaihuaFeng,GuangmingWang,LihuiLiu,QiyunShi,FenggeShen,MingxunXing,PengYuan,MingyuanLiu,LuYu.TranscriptionalandFunctionalAnalysisShowsSodiumHouttuyfonate-MediatedInhibitionofAutolysisinStaphylococcusaureus.Molecules2011,16(10),8848-8865.(影响因子:1.974,通讯作者)
LiL,LiZ,GuoN,JinJ,DuR,LiangJ,WuX,WangX,LiuM,JinQ,YuL.Synergisticactivityof1-(1-Naphthylmethyl)-piperazinewithciprofloxacinagainstclinicallyresistantStaphylococcusaureus,asdeterminedbydifferentmethods.LettApplMicrobiol.2011,doi:10.1111/j.1472-765X.2011.03010.x.(影响因子:1.906,通讯作者)
JinJ,GuoN,ZhangJ,DingY,TangX,LiangJ,LiL,DengX,YuL.TheSynergyofHonokiolandFluconazoleagainstClinicalIsolatesofAzole-ResistantCandidaalbicans.LettApplMicrobiol.2010,51(3):351-357.(影响因子:1.906,通讯作者)
QiuJ,JiangY,XiaL,XiangH,FengH,PuS,HuangN,YuL,DengX.SubinhibitoryconcentrationsoflicochalconeAdecreasealpha-toxinproductioninbothmethicillin-sensitiveandmethicillin-resistantStaphylococcusaureusisolates.LettApplMicrobiol.2010,50(2):223-229.(影响因子:1.906,通讯作者)
GuoN,LiangX,LinG,JinJ,QiuJ,FanJ,SongY,HuangN,WuX,WangX,DengX,DengX,YuL.InVitroSynergyofPseudolaricAcidBandFluconazoleagainstClinicalIsolatesofCandidaalbicans.Mycoses.2010,DOI:10.1111/j.1439-0507.2010.01935.x.(影响因子:1.74,通讯作者)
ChenZ,ZhangX,ChuX,ZhangX,SongK,JiangY,YuL,DengX.Preventiveeffectsofvalnemulinonlipopolysaccharide-inducedacutelunginjuryinmice.Inflammation.2010,33(5):306-14.(影响因子:1.871,通讯作者).
FenggeShen,MingxunXing,LihuiLiu,XudongTang,WeiWang,XiaohongWang,XiupingWu,XuelinWang,XinruiWang,GuangmingWang,JunhuiZhang,LeiLi,JiyuZhang,LuYu.Efficacyoftrans-cinnamaldehydeagainstPsoroptescuniculiinvitro.ParasitologyResearch.2011,DOI:10.1007/s00436-012-2816-y.Online.(影响因子:1.723,通讯作者)
FengH,XiangH,ZhangJ,LiuG,GuoN,WangX,WuX,DengX,YuL.Genome-widetranscriptionalprofilingoftheresponseofStaphylococcusaureustoCryptotanshinone.JBiomedBiotechnol.2009,2009:617509.(影响因子:1.739,通讯作者)
LiangJ,ZengF,GuoA,LiuL,GuoN,LiL,JinJ,WuX,LiuM,ZhaoD,LiY,JinQ,YuL.MicroarrayAnalysisoftheChelerythrine-InducedTranscriptomeofMycobacteriumtuberculosis.CurrMicrobiol.2010,doi:10.1007/s00284-010-9837-5.(影响因子:1.547,通讯作者)
GeF,ZengF,GuoN,FanJ,SongY,LiuS,WuX,WangX,DengX,JinQ,YuL.Invitrosynergisticactivitybetween8-methoxypsoralenandethambutol,isoniazid,andrifampinwhenusedincombinationagainstMycobacteriumtuberculosis.WorldJMicrobBiot.2010,26(4):623-628.(影响因子:1.312,通讯作者).
YeH,LiuZ,GuoA,LiangJ,GuoN,ZengF,LiuL,LiL,JinJ,WuX,LiY,LiuM,JinQ,YuL.GlobaltranscriptionalprofilesofMycobacteriumtuberculosistreatedwithplumbagin.WorldJMicrobBiot.2011,27(10):2261-2269.(影响因子:1.312,通讯作者)
XingM,ShenF,LiuL,ChenZ,GuoN,WangX,WangW,ZhangK,WuX,WangX,LiY,SunS,YuL.AntimicrobialefficacyofthealkaloidharmalinealoneandincombinationwithchlorhexidinedigluconateagainstclinicalisolatesofStaphylococcusaureusgrowninplanktonicandbiofilmcultures.LettApplMicrobiol.2012,doi:10.1111/j.1472-765X.2012.03233.x.(影响因子:1.906,通讯作者)
JunchaoLiang,XudongTang,NaGuo,KaiyuZhang,AizhenGuo,XiupingWu,XuelinWang,ZhenhongGuan,LihuiLiu,FenggeShen,MingxunXing,LiqiangLiu,LeiLi,LuYu.Genome-wideexpressionprofilingoftheresponsetoLinezolidinMycobacteriumtuberculosis.CurrMicrobiol.2012,DOI10.1007/s00284-012-0104-9.(影响因子:1.547,通讯作者)
LeiLi,WeiminShen,KaiyuZhang,XudongTang,NaGuo,FenggeShen,MingxunXing,LihuiLiu,PengYuan,QiyunShi,JunchaoLiang,LuYu.Invitroantimycoplasmalactivityoftriclosanincombinationwithfluoroquinolonesagainstfivemycoplasmaspecies.IranianJournalofPharmaceuticalResearch.2012,ManuscriptID:2505-IJPR.Accepted.(影响因子:0.651,通讯作者)
XuelinWang,JuanLiu,XiupingWu,LuYu,HaiyingChen,HengGuo,MaolinZhang,HuipingLi,XueLiu,ShuminSun,LijingZhao,XinyueZhang,LifangGao,MingyuanLiu.Oralimmunisationofmicewitharecombinantrabiesvirusvaccineincorporatingtheheat-labileenterotoxinBsubunitofEscherichiacoliinanattenuatedSalmonellastrain.ResearchinVeterinaryScience.2011,Online.(影响因子:1.544,通讯作者)
WeiJ,GuoN,LiangJ,YuanP,ShiQ,TangX,YuL.DNAmicroarraygeneexpressionprofileofMycobacteriumtuberculosiswhenexposedtoosthole.PolJMicrobiol.2013,62(1):23-30.出版时间:2012.11(影响因子:0.768,通讯作者)
ZhangW,YuL,YangJ,WangL,PengJ,JinQ.TranscriptionalprofilesofresponsetoterbinafineinTrichophytonrubrum.ApplMicrobiolBiotechnol.2009,82(6):1123-1130.(影响因子:3.264)
QiuJ,FengH,XiangH,WangD,XiaL,JiangY,SongK,LuJ,YuL,DengX.InfluenceofsubinhibitoryconcentrationsoflicochalconeAonthesecretionofenterotoxinsAandBbyStaphylococcusaureus.FEMSMicrobiolLett.2010,307(2):135-141.(影响因子:2.354)
DuY,QiY,YuL,LinJ,LiuS,NiH,PangH,LiuH,SiW,ZhaoH,WangC.MolecularcharacterizationofMycobacteriumtuberculosiscomplex(MTBC)isolatedfromcattleinnortheastandnorthwestChina.ResVetSci.2010,doi:10.1016/j.rvsc.2010.07.020.(影响因子:1.466)
CiX,LiH,YuQ,ZhangX,YuL,ChenN,SongY,DengX.Avermectinexertsanti-inflammatoryeffectbydownregulatingthenucleartranscriptionfactorkappa-Bandmitogen-activatedproteinkinaseactivationpathway.FundamClinPharmacol.2009,23(4):449-455.(影响因子:2.245)
CaoY,SongY,AnN,ZengS,WangD,YuL,ZhuT,ZhangT,CuiJ,ZhouC,DengX.TheeffectsoftelocinobufaginisolatedfromChanSuontheactivationandcytokinesecretionofimmunocytesinvitro.FundamClinPharmacol.2009,23(4):457-464.(影响因子:2.245).
WuXP,FuBQ,WangXL,YuL,YuSY,DengHK,LiuXY,BoireauP,WangF,LiuMY.IdentificationofantigenicgenesinTrichinellaspiralisbyimmunoscreeningofcDNAlibraries.VetParasitol.2009,159(3-4):272-275.(影响因子:2.432)
ZhangX,SongY,XiongH,CiX,LiH,YuL,ZhangL,DengX.InhibitoryeffectsofivermectinonnitricoxideandprostaglandinE2productioninLPS-stimulatedRAW264.7macrophages.IntImmunopharmacol.2009,9(3):354-359.(影响因子:2.312).
LiA,LiuZ,LiQ,YuL,WangD,DengX.ConstructionandcharacterizationofbidirectionalexpressionvectorsinSaccharomycescerevisiae.FEMSYeastRes.2008,8(1):6-9.(影响因子:2.403)
ZouL,ZhuT,XiangH,YuL,YanZ,GanS,WangD,ZengS,DengX.NewsecoiridoidglycosidesfromtherootsofPicrorhizascrophulariiflora.Molecules.2008,13(9):2049-2057.(影响因子:1.608)
LiuT,ZhangQ,WangL,YuL,LengW,YangJ,ChenL,PengJ,MaL,DongJ,XuX,XueY,ZhuY,ZhangW,YangL,LiW,SunL,WanZ,DingG,YuF,TuK,QianZ,LiR,ShenY,LiY,JinQ.TheuseofglobaltranscriptionalanalysistorevealthebiologicalandcellulareventsinvolvedindistinctdevelopmentphasesofTrichophytonrubrumconidialgermination.BMCGenomics.2007,8:100.(影响因子:4.179)
YangLi,WangLingling,PengJunping,YuLu,LiuTao,LengWenchuan,YangJian,CHenLihong,ZhangWenliang,ZhangQian,QiYipeng,JinQi.ComparisonbetweengeneexpressionofconidiaandgerminatingphaseinTrichophytonrubrum.SciChinaCLifeSci.2007,50(3):377-384.(影响因子:0.708)
BaiX,WuX,WangX,GuanZ,GaoF,YuJ,YuL,TangB,LiuX,SongY,WangX,RaduB,BoireauP,WangF,LiuM.Regulationofcytokineexpressioninmurinemacrophagesstimulatedbyexcretory/secretoryproductsfromTrichinellaspiralisinvitro.MolCellBiochem.2012,360(1-2):79-88.(影响因子:2.168)
WangL,MaL,LengW,LiuT,YuL,YangJ,YangL,ZhangW,ZhangQ,DongJ,XueY,ZhuY,XuX,WanZ,DingG,YuF,TuK,LiY,LiR,ShenY,JinQ.AnalysisofthedermatophyteTrichophytonrubrumexpressedsequencetags.BMCGenomics.2006,7:255.(影响因子:4.179)
2.出版论著
《药物残留检测》.哈尔滨工业大学出版社.2011.8.1主编.ISBN9787560333823
《药物毒理学》.黑龙江科学技术出版社,哈尔滨.2009.11主编.ISBN9787538862072
《动物疾病病理诊断学》.科学出版社,北京.2010.1.1副主编.ISBN9787030266538
《当代世界人兽共患病学》.四川科学技术出版社,北京.2011.3.1参编.ISBN9787536471665
《兽医公共卫生学》（国家规划教材），中国轻工业出版社，北京.2009,参编.
《畜禽药物手册》（全国优秀畅销书）.金盾出版社,北京.2007,参编.
3.获得授权专利
于录,邓旭明,金晶,唐旭东,郭娜,梁俊超,李蕾.一种具有与氟康唑协同抗真菌作用的增效剂.国家专利申请号:201010196758.9.
于录,邓旭明,郭娜,金晶,李蕾,梁俊超.一种提高氟康唑抗真菌作用的增效剂.国家专利申请号:201010196759.3.
于录,邓旭明,郭娜,金晶,梁俊超,李蕾.三氯生作为抗真菌药物氟康唑增效剂的新用途.国家专利申请号:201010196773.3.
于录,韩文瑜,孙长江,郭娜,金晶,梁俊超,李蕾.一种提高乙胺丁醇抗分支杆菌作用的增效剂.国家专利申请号:201010188042.4.
