硫唑嘌呤的英文说明是什么?
药理作用Classification:ImmunosuppressantAction/Kinetics:Antimetabolitethatisquicklysplittoformmercaptopurine。 Tobeeffective,thedrugmustbegivenduringtheinductionperiodoftheantibodyresponse。Theprecisemechanismindepressingtheimmuneresponseisunknown,butitsuppressescell-mediatedhypersensitivitiesandalters...全部
药理作用Classification:ImmunosuppressantAction/Kinetics:Antimetabolitethatisquicklysplittoformmercaptopurine。
Tobeeffective,thedrugmustbegivenduringtheinductionperiodoftheantibodyresponse。Theprecisemechanismindepressingtheimmuneresponseisunknown,butitsuppressescell-mediatedhypersensitivitiesandaltersantibodyproduction。
InhibitssynthesisofDNA,RNA,andproteinsandmayinterferewithmeiosisandcellularmetabolism。Themechanismforitseffectonautoimmunediseasesisnotknown。
IsreadilyabsorbedfromtheGItract。Thanuricclientmanifestsincreasedeffectivenessandtoxicity(uptotwofold)。
Onset:6-8weeksforrheumatoidarthritis。t1/2:3hr。适应症Asanadjuncttopreventrejectioninrenalhomotransplantation。
InadultclientsmeetingcriteriaforclassicordefiniterheumatoidarthritisasdefinedbytheAmericanRheumatismAssociation。
Restrictusetoclientswithsevere,active,anderosivediseasethatisnotresponsivetoconventionaltherapy。
Investigational:Chroniculcerativecolitis,generalizedmyastheniagravis,tocontroltheprogressionofBehet'ssyndrome(especiallyeyedisease),Crohn'sdisease(lowdoses)。
用法用量Tablets,IVUseinrenalhomotransplantation。Adultsandchildren,initial:3-5mg/kg(120mg/m2),1-3daysbeforeoronthedayoftransplantation;maintenance:1-3mg/kg(45mg/m2)daily。
Rheumatoidarthritis,SLE。Adultsandchildren,tablets,initial:1mg/kg(50-100mg);then,increasedoseby0。
5mg/kg/dayafter6-8weeksandthereafterq4weeks,uptomaximumof2。5mg/kg/day;maintenance:lowesteffectivedose。
Dosageshouldbereducedinclientswithrenaldysfunction。Myastheniagravis。2-3mg/kg/day。However,sideeffectsoccurinmorethan35%ofclients。
TocontrolprogressionofBehet'ssyndrome。2。5mg/kg/day。TotreatCrohn'sdisease。75-100mg/day。注意事项PregnancyCategory:DContraindications:Treatmentofrheumatoidarthritisinpregnancyorinclientspreviouslytreatedwithalkylatingagents。
Pregnancyandlactation。SpecialConcerns:Hematologictoxicityisdose-relatedandmayoccurlateinthecourseoftherapy;maybemoresevereinrenaltransplantclientsundergoingrejection。
Althoughusedinchildren,safetyandefficacyhavenotbeenestablished。不良反应Hematologic:Leukopenia,thrombocytopenia,macrocyticanemia,severebonemarrowdepressionselectiveerythrocyteaplasia。
GI:N&V,diarrhea,abdominalpain,steatorrhea。CNS:Fever,malaise。Other:Increasedriskofcarcinomasevereinfections(fungal,viral,bacterial,andprotozoal),andhepatotoxicityaremajorsideeffects。
Also,skinrashes,alopecia,myalgias,increaseinliverenzymes,hypotension,negativenitrogenbalance。相互作用ACEinhibitors/↑RiskofsevereleukopeniaAllopurinol/↑PharmacologiceffectofazathioprineR/T↓liverbreakdownAnticoagulants/↓AnticoagulanteffectCorticosteroids/Withazathioprine,maycausemusclewastingafterprolongedtherapyCyclosporine/↑PlasmacyclosporinelevelsEchinacea/DonotgivewithazathioprineMethotrexate/↑Plasmalevelsoftheactivemetabolite,6-mercaptopurineTubocurarine/↓Tubocurarineeffectandothernondepolarizingneuromuscularblockingagents药物过量Symptoms:Largedosesmayresultinbonemarrowhypoplasiableeding,infection,anddeath。
Treatment:Approximately45%canberemovedfromthebodyfollowing8hrofhemodialysis。收起